TY  - JOUR
PY  - 2003//
TI  - Warfarin therapy and risk of hip fracture among elderly patients
JO  - Pharmacotherapy
A1  - Mamdani, Muhammad
A1  - Upshur, Ross E. G.
A1  - Anderson, Geoff
A1  - Bartle, Bill R.
A1  - Laupacis, Andreas
SP  - 1
EP  - 4
VL  - 23
IS  - 1
N2  - STUDY OBJECTIVE: To ascertain the relationship between warfarin therapy and subsequent hip fracture in a large elderly population. DESIGN: Retrospective, population-based cohort study. SETTING: Population-based health care administrative databases for Ontario, Canada. PATIENTS: Elderly patients receiving warfarin (52,701 patients), thyroid replacement therapy (40,555), an oral corticosteroid (43,915), or a proton pump inhibitor (60,383). The proton pump inhibitor group served as controls. MEASUREMENTS AND MAIN RESULTS: The association between warfarin therapy and subsequent hospitalization for hip fracture in elderly patients was examined by researching administrative data from January 1, 1994-March 31, 1999, for the elderly population of Ontario. Relative to patients receiving proton pump inhibitors, patients receiving warfarin (adjusted risk ratio [aRR] 0.94, 95% confidence interval [CI] 0.81-1.09) or thyroid replacement therapy (aRR 1.02, 95% Cl 0.89-1.18) incurred similar risks of hip fracture. As expected, patients receiving oral corticosteroids incurred an increased risk (aRR 1.44, 95% CI 1.21-1.70) relative to patients receiving proton pump inhibitors. CONCLUSION: Warfarin was not associated with increased risk of hip fracture.<p /> <p>Language: en</p>
LA  - en
SN  - 0277-0008
UR  - http://dx.doi.org/
ID  - ref1
ER  -