TY - JOUR PY - 2003// TI - Safety of paracetamol as a representative of nonprescription analgetics-antipyretics JO - Klinicheskaia meditsina A1 - Makar'iants, M. L. SP - 58 EP - 60 VL - 81 IS - 4 N2 - Paracetamol is a well-known analgetic-antipiretic drug widely used in medical practice. In therapeutic doses (4 g/day for adults and 60 mg/kg/day for children) paracetamol relieves fever and non-severe pain with minimal risk of complications both in adults and children. But medical professionals should know that in extremely high doses (above 10 g for adults) paracetamol has a hepatotoxic effect. Overdose intake of paracetamol in Russia happens rarely, it occurs by chance or in attempted suicide. In such a case the antidote must be used to protect the liver. This antidote for paracetamol is N-acetylcysteine.

Language: ru

LA - ru SN - 0023-2149 UR - http://dx.doi.org/ ID - ref1 ER -