TY  - JOUR
PY  - 1999//
TI  - Admission level of Gc-globulin predicts outcome after multiple trauma
JO  - Injury
A1  - Dahl, B.
A1  - Schiødt, F. V.
A1  - Nielsen, M.
A1  - Kiaer, T.
A1  - Williams, J. G.
A1  - Ott, P.
SP  - 275
EP  - 281
VL  - 30
IS  - 4
N2  - BACKGROUND: Actin is the dominating protein in mammalian cells. Release of excessive amounts of actin into the circulation may result in a condition resembling multiple organ failure. The purpose of this study was to determine if admission levels of Gc-globulin can predict survival after multiple trauma. Also, we wanted to compare the predictive ability of Gc-globulin with that of the TRISS-Like scoring system. METHODS: Fifty-seven patients with a median ISS 18 (16-75) were included. All patients had a blood sample taken median 42 min after the injury (19-110 min). Serum Gc-globulin was measured by rocket immunoelectrophoresis. RESULTS: On admission, all patients had significantly reduced levels of Gc-globulin compared with normal controls. Gc-globulin was significantly higher in the group of survivors (n = 41), compared with non-survivors (n = 16). Median 237 mg/l vs. 188 mg/l (P < 0.01). The predictive ability of Gc-globulin regarding death was similar to that of TRISS-Like with positive predictive values of 69%, a negative predictive value of 84%, a sensitivity of 56% and a specificity of 90%. CONCLUSIONS: The predictive value of Gc-globulin regarding survival was similar to that of an established scoring system. Gc-globulin, alone or in combination with other parameters, may serve as a routine tool for early identification of patients at risk after severe injury, increasing the possibility of early intervention.<p /> <p>Language: en</p>
LA  - en
SN  - 0020-1383
UR  - http://dx.doi.org/
ID  - ref1
ER  -