TY  - JOUR
PY  - 1999//
TI  - Long-lasting sensitization to the accelerating effects of amphetamine on the speed of an internal clock
JO  - Behavioural brain research
A1  - Badiani, A.
A1  - Stewart, J.
SP  - 217
EP  - 223
VL  - 100
IS  - 1-2
N2  - Drinking in the rat occurs in bursts of rapid licking, a high frequency rhythmic behavior controlled by a neural clock located in the brain stem. We found that 3.0 mg/kg amphetamine increased the speed of licking and shifted to the left the frequency distribution of inter-lick intervals. Repeated amphetamine treatments result in long-lasting sensitization to this effect. Thus, it appears possible to produce enduring changes in the activity of a biological interval clock (or 'stopwatch') by manipulating catecholaminergic transmission. These findings may be important for an understanding of the neural basis of normal and pathological timing behavior.<p /> <p>Language: en</p>
LA  - en
SN  - 0166-4328
UR  - http://dx.doi.org/
ID  - ref1
ER  -