TY  - JOUR
PY  - 1999//
TI  - Pathways of muscle protein breakdown in injury and sepsis
JO  - Current opinion in clinical nutrition and metabolic care
A1  - Hasselgren, P. O.
SP  - 155
EP  - 160
VL  - 2
IS  - 2
N2  - The purpose of this article is to review evidence that the ubiquitin-proteasome proteolytic pathway plays an important role in injury- and sepsis-induced muscle catabolism. Such evidence includes upregulated gene expression of several of the components of the ubiquitin-proteasome pathway as well as energy-dependency of the injury- and sepsis-induced muscle protein breakdown. Although the ubiquitin-proteasome pathway is the predominant mechanism of muscle breakdown in various catabolic conditions, other proteolytic mechanisms, in particular calcium-dependent, calpain-mediated protein degradation, probably participate as well.<p /> <p>Language: en</p>
LA  - en
SN  - 1363-1950
UR  - http://dx.doi.org/
ID  - ref1
ER  -