TY  - JOUR
PY  - 2012//
TI  - Changes caused by haloperidol are blocked by music in Wistar rat
JO  - Journal of physiology and biochemistry
A1  - Tasset, Inmaculada
A1  - Quero, Ismael
A1  - García-Mayórgaz, Angel D.
A1  - Del Río, Manuel Causse
A1  - Túnez, Isaac
A1  - Montilla, Pedro
SP  - 175
EP  - 179
VL  - 68
IS  - 2
N2  - This study sought to evaluate the effect of classical music, using Mozart's sonata for two pianos (K. 448), on changes in dopamine (DA) levels in the striatal nucleus (SN), prefrontal cortex (PFC) and mesencephalon, and on prolactin (PRL) and corticosterone secretion in adult male Wistar rats. Rats were divided into four groups: (1) control, (2) haloperidol treatment (single dose of 2 mg/kg s.c.), (3) music (two 2-h sessions per day) and (4) haloperidol plus music. Rats were sacrificed 2 h after haloperidol injection. Music prompted a fall in plasma PRL and corticosterone levels in healthy rats (P < 0.05) and prevented the increase in levels triggered by haloperidol (P < 0.001). Moreover, exposure to music was associated with a significant increase in DA levels in all groups, with the increase being particularly marked in PFC and SN (P < 0.001). Haloperidol is a recognised D2 receptor antagonist, and these findings suggest that music, by contrast, enhances DA activity and turnover in the brain. The results obtained here bear out reports that music triggers a reduction in systolic pressure and an increase in mesencephalon dopamine levels in human and rats treated with ecstasy, through a calmodulin-dependent system.<p />  <p>Language: en</p>
LA  - en
SN  - 1138-7548
UR  - http://dx.doi.org/10.1007/s13105-011-0129-8
ID  - ref1
ER  -