TY  - JOUR
PY  - 2013//
TI  - Individual differences in neural correlates of fear conditioning as a function of 5-HTTLPR and stressful life events
JO  - Social cognitive and affective neuroscience
A1  - Klucken, T.
A1  - Alexander, N.
A1  - Schweckendiek, J.
A1  - Merz, C. J.
A1  - Kagerer, S.
A1  - Osinsky, R.
A1  - Walter, B.
A1  - Vaitl, D.
A1  - Hennig, J.
A1  - Stark, R.
SP  - 318
EP  - 325
VL  - 8
IS  - 3
N2  - Fear learning is a crucial process in the pathogeneses of psychiatric disorders, which highlights the need to identify specific factors contributing to interindividual variation. We hypothesized variation in the serotonin transporter gene (5-HTTLPR) and stressful life events (SLEs) to be associated with neural correlates of fear conditioning in a sample of healthy male adults (N=47). Subjects were exposed to a differential fear conditioning paradigm after being preselected regarding 5-HTTLPR genotype and SLEs. Individual differences in brain activity as measured by fMRI, skin conductance responses and preference ratings were assessed. We report significant variation in neural correlates of fear conditioning as a function of 5-HTTLPR genotype. Specifically, the conditioned stimulus (CS+) elicited elevated activity within the fear-network (amygdala, insula, thalamus, occipital cortex) in subjects carrying two copies of the 5-HTTLPR S' allele. Moreover, our results revealed preliminary evidence for significant gene-by-environment interaction, such as homozygous carriers of the 5-HTTLPR S' allele with a history of SLEs demonstrated elevated reactivity to the CS+ in the occipital cortex and the insula. Our findings contribute to the current debate on 5-HTTLPR × SLEs interaction by investigating crucial alterations on an intermediate phenotype level which may convey elevated vulnerability for the development of psychopathology.<p />  <p>Language: en</p>
LA  - en
SN  - 1749-5016
UR  - http://dx.doi.org/10.1093/scan/nss005
ID  - ref1
ER  -