TY  - JOUR
PY  - 2011//
TI  - Histopathological changes induced by Hemiscorpius lepturus scorpion venom in mice
JO  - Toxicon: Journal of the International Society on Toxinology
A1  - Heidarpour, Mojgan
A1  - Ennaifer, Emna
A1  - Ahari, Hamed
A1  - Srairi-Abid, Najet
A1  - Borchani, Lamia
A1  - Khalili, Ghader
A1  - Amini, Hossein
A1  - Anvar, Amir Ali
A1  - Boubaker, Samir
A1  - El-Ayeb, Mohamed
A1  - Shahbazzadeh, Delavar
SP  - 373
EP  - 378
VL  - 59
IS  - 3
N2  - Envenomation by Hemiscorpius lepturus (H. lepturus) is associated with local necrosis, followed by systemic manifestations. In this work the LD(50) of H. lepturus venom were determined by subcutaneous (SC) injection in white Balb/c mice (5 mg/kg). Histopathological alterations in organs such as kidney, heart, liver, lungs, stomach and intestine were determined in 3, 6, 12 and 24 h following experimental (SC) envenoming injection of one LD(50) of the venom in Balb/c mice. Histological studies showed degenerative changes in the kidney with disorganized glomeruli and necrotic tubular in 3 h and reached to its climax in 6 h. Myocardium showed massive myocytolysis with interstitial necrosis in 3 h and reached to its peak after 6 h past envenoming. Bowels showed edema of lamina propria and slight villous necrosis. The enzymatic activities of creatine kinase (CK) and lactate dehydrogenase (LDH) were significantly increased in the serum in 9 h. No necrotic lesion observed in lungs and liver. The results indicate that the venom of H. lepturus is a highly cytotoxic, and induces massive tissue damages in specific organs, starting from the heart and kidney as the first target in 3 h and ends to the bowels in 6 h post envenomation.<p />  <p>Language: en</p>
LA  - en
SN  - 0041-0101
UR  - http://dx.doi.org/10.1016/j.toxicon.2011.12.011
ID  - ref1
ER  -