TY  - JOUR
PY  - 2011//
TI  - Clinical predictors of familial depression in Han Chinese women
JO  - Depression and anxiety
A1  - Wang, Lina
A1  - Qiao, Dongdong
A1  - Li, Yihan
A1  - Wang, Liwei
A1  - Ren, Jianer
A1  - He, Kangmei
A1  - Sun, Jing
A1  - Wang, Zhoubing
A1  - Tian, Tian
A1  - Chen, Ce
A1  - Yang, Lei
A1  - Hu, Jian
A1  - Deng, Hong
A1  - Wang, Qian
A1  - Li, Keqing
A1  - Han, Jiyang
A1  - Rong, Han
A1  - Gan, Zhaoyu
A1  - Yang, Hong
A1  - Zhou, Pingliang
A1  - Pan, Jiyang
A1  - Zhou, Cong
A1  - Cui, Yanping
A1  - Song, Libo
A1  - Zhu, Yuzhang
A1  - Li, Ying
A1  - Wang, Xueyi
A1  - Ye, Lanxian
A1  - Liang, Wei
A1  - Chen, Yunchun
A1  - Tang, Qingjun
A1  - Guan, Jing
A1  - Shi, Shenxun
A1  - Kendler, Kenneth S.
A1  - Flint, Jonathan
A1  - Liu, Lanfen
SP  - 10
EP  - 15
VL  - 29
IS  - 1
N2  - Background: A number of clinical features potentially reflect an individual's familial vulnerability to major depression (MD), including early age at onset, recurrence, impairment, episode duration, and the number and pattern of depressive symptoms. However, these results are drawn from studies that have exclusively examined individuals from a European ethnic background. We investigated which clinical features of depressive illness index familial vulnerability in Han Chinese females with MD. Methods: We used lifetime MD and associated clinical features assessed at personal interview in 1,970 Han Chinese women with DSM-IV MD between 30-60 years of age. Odds Ratios were calculated by logistic regression. Results: Individuals with a high familial risk for MD are characterized by severe episodes of MD without known precipitants (such as stress life events) and are less likely to feel irritable/angry or anxious/nervous. Conclusions: The association between family history of MD and the lack of a precipitating stressor, traditionally a characteristic of endogenous or biological depression, may reflect the association seen in other samples between recurrent MD and a positive family history. The symptomatic associations we have seen may reflect a familial predisposition to other dimensions of psychopathology, such as externalizing disorders or anxiety states. Depression and Anxiety 0:1-6, 2011.  © 2011 Wiley Periodicals, Inc.<p />  <p>Language: en</p>
LA  - en
SN  - 1091-4269
UR  - http://dx.doi.org/10.1002/da.20878
ID  - ref1
ER  -