TY  - JOUR
PY  - 1975//
TI  - Ventricular function following acute carbon monoxide exposure
JO  - Journal of applied physiology (APS DC)
A1  - Cramlet, S. H.
A1  - Erickson, H. H.
A1  - Gorman, H. A.
SP  - 482
EP  - 486
VL  - 39
IS  - 3
N2  - Cardiac output function curves were used to investigate the effects of carbon monoxide on the heart in the conscious dog. Each dog was briefly exposed to 1,500 ppm carbon monoxide through a permanent tracheostomy. Immediately upon attaining either 10%, 20%, or 30% HbCO a rapid infusion of Ringer's lactate was given to test cardiac capabilities. The combined effects of carbon monoxide and infusion produced significant increases in cardiac output, heart rate, mean left ventricular pressure, dP/dt and (dP/dt)/IP. Cardiac output was sufficient to prevent peripheral hypoxia at all HbCO levels; however, there was evidence of impending cardiac depression beginning at 20% HbCO.<p /> <p>Language: en</p>
LA  - en
SN  - 0021-8987
UR  - http://dx.doi.org/
ID  - ref1
ER  -