TY  - JOUR
PY  - 1998//
TI  - Regional cerebral blood volume after severe head injury in patients with regional cerebral ischemia
JO  - Neurosurgery
A1  - Schröder, M. L.
A1  - Muizelaar, J. P.
A1  - Fatouros, P. P.
A1  - Kuta, A. J.
A1  - Choi, S. C.
SP  - 1276
EP  - 80; discussion 1280
VL  - 42
IS  - 6
N2  - OBJECTIVE: Recent early cerebral blood flow (CBF) studies in cases of severe head injury have revealed ischemia in a substantial number of patients with a variety of computed tomographically demonstrated diagnoses. The underlying derangements causing this early ischemia are unknown, but cerebral blood volume (CBV) measurements might offer some insight into this pathological abnormality. METHODS: For this purpose, stable xenon-enhanced computed tomography was used for assessment of CBF, and a dynamic computed tomographic imaging technique was used for determining CBV. Based on the occurrence of regional ischemia (CBF < 20 ml/100 g/min), seven patients with varying anatomic lesions revealed by computed tomography were identified for comparison between CBF and CBV in ischemic and nonischemic areas. RESULTS: Both CBF (15+/-4.3 versus 34+/-11 g/min, P < 0.002) and CBV (2.5+/-1.0 versus 4.9+/-1.9 ml/100 g) exhibited significantly lower values in the ischemic zones than in the nonischemic zones (means+/-standard deviations). Among 26 patients with or without ischemia observed during their initial follow-up studies, which were conducted between Days 2 and 8, all patients showed CBF and CBV values within the low-normal range. CONCLUSION: These data evidently support the suggestion that compromise of the microvasculature is the cause of early ischemia, rather than vasospasm of the larger conductance vessels.<p /> <p>Language: en</p>
LA  - en
SN  - 0148-396X
UR  - http://dx.doi.org/
ID  - ref1
ER  -