TY  - JOUR
PY  - 1998//
TI  - Risk of death or incapacitation after heart transplantation, with particular reference to pilots
JO  - Journal of heart and lung transplantation: the official publication of the International Society for Heart Transplantation
A1  - McGiffin, D. C.
A1  - Naftel, D. C.
A1  - Spann, J. L.
A1  - Kirklin, J. K.
A1  - Young, J. B.
A1  - Bourge, R. C.
A1  - Mills, R. M.
SP  - 497
EP  - 504
VL  - 17
IS  - 5
N2  - Pilots who have received a heart transplant may subsequently want to resume flying. This study was undertaken to determine whether a group of heart transplant recipients who had a particularly low risk of sudden unexpected death could be identified from clinical data. An event, "rapid-onset death," was defined incorporating a number of possible causes of death that could result in a heart transplant recipient-pilot losing control of an airplane. The survival of 3676 patients undergoing a first heart transplantation was 85% and 73% at 1 and 5 years, respectively, the hazard function having a high early phase of risk. When time zero was moved to the beginning of the second year after transplantation, the freedom from "rapid-onset death" at posttransplantation year 2 and posttransplantation year 5 was 96.8% and 88%, respectively. For patients who had both a "normal" coronary angiogram and no episodes of acute heart rejection during the first year transplantation, the probability of "rapid onset death" during the second posttransplantation year was 1.4%, and given the same circumstances, during the third posttransplantation year the risk of "rapid-onset death" was 1.6%. This information is potentially useful to the Federal Aviation Administration for policy decisions regarding this issue.<p /> <p>Language: en</p>
LA  - en
SN  - 1053-2498
UR  - http://dx.doi.org/
ID  - ref1
ER  -