TY  - JOUR
PY  - 1990//
TI  - Schedule-induced cocaine drinking: choice between cocaine and vehicle
JO  - Pharmacology, biochemistry, and behavior
A1  - Falk, J. L.
A1  - Vigorito, M.
A1  - Tang, M.
A1  - Lau, C. E.
SP  - 187
EP  - 193
VL  - 35
IS  - 1
N2  - Rats were exposed to daily 3-hr schedule-induced polydipsia sessions (fixed-time 1-min food-pellet delivery) with two drinking fluids available: cocaine solution and water. Fluid position was alternated daily. Polydipsia occurred mostly from a preferred-side spout (position preference) until cocaine solution concentration was increased to between 0.52 and 1.04 mg/ml and animals drank mostly water. Within a lower concentration range (0.28-0.6 mg/ml) maximum session cocaine intakes ranged from 54.3 to 120.1 mg/kg. Postsession serum cocaine levels were about 200 ng/ml. At individually chosen cocaine solution concentrations, the addition of saccharin to the solution did not increase cocaine intake, but a compound solution (saccharin plus glucose) did. With progressive dilution of the compound vehicle, an almost complete preference for cocaine solution was maintained. But with a return to water as the vehicle, animals reverted to a position preference after a few sessions, although one maintained a clear cocaine preference. Schedule-induced polydipsia produced chronic, oral self-administration of cocaine resulting in pharmacologically significant intakes and serum levels.<p /> <p>Language: en</p>
LA  - en
SN  - 0091-3057
UR  - http://dx.doi.org/
ID  - ref1
ER  -