TY  - JOUR
PY  - 1991//
TI  - Hemostatic changes due to the venom gland extract of the red-necked keelback snake (Rhabdophis subminiatus)
JO  - Toxicon: Journal of the International Society on Toxinology
A1  - Zotz, R. B.
A1  - Mebs, D.
A1  - Hirche, H.
A1  - Paar, D.
SP  - 1501
EP  - 1508
VL  - 29
IS  - 12
N2  - After a bite by the aglyphous red-necked keelback snake Rhabdophis subminiatus a complete defibrinogenation syndrome with severe hemorrhagic diathesis developed in a 25-year-old man. In vitro studies showed that the venom gland extract of the snake contains a very active prothrombin (Factor II) activator. The thrombin generated is inhibited neither by antithrombin III nor the antithrombin-III-heparin complex. The venom gland extract stimulated also the tissue plasminogen activator; however, it did not cause direct activation of plasminogen, protein C, Factor X or direct degradation of fibrinogen.<p /> <p>Language: en</p>
LA  - en
SN  - 0041-0101
UR  - http://dx.doi.org/
ID  - ref1
ER  -