TY  - JOUR
PY  - 2011//
TI  - Immune Response Towards Snake Venoms
JO  - Inflammation and allergy - drug targets
A1  - León, Guillermo
A1  - Sánchez, Laura
A1  - Hernández, Andrés
A1  - Villalta, Mauren
A1  - Herrera, María
A1  - Segura, Alvaro
A1  - Estrada, Ricardo
A1  - Gutiérrez, José María
SP  - 381
EP  - 398
VL  - 10
IS  - 5
N2  - The immune response involves a complex repertoire of innate and adaptive responses to foreign agents in the organism. The present review focuses on the immune response to snake venoms, including those occurring in snakebite accidental envenomation, experimental vaccination and animal hyperimmunization for snake antivenom production. The following aspects are considered: (a) the structural characteristics of snake toxins and their relationship to immunogenicity, (b) the effects that factors such as administration route, venom dose, type of adjuvant, and individual and species characteristics of the immunized animal have on the immune response, (c) the initial venom-induced inflammatory response, (d) the process by which specific antibodies towards individual toxins are produced, and (e) the techniques currently used to evaluate the antibody response. Understanding the immune response to snake venoms is highly relevant for improving antivenom production and for gaining a more complete view of snakebite envenoming.<p /> <p>Language: en</p>
LA  - en
SN  - 1871-5281
UR  - http://dx.doi.org/
ID  - ref1
ER  -