TY  - JOUR
PY  - 2011//
TI  - Clinical predictors of response and remission in inpatients with depressive syndromes
JO  - Journal of affective disorders
A1  - Riedel, Michael
A1  - Moller, Hans-Jurgen
A1  - Obermeier, Michael
A1  - Adli, Mazda
A1  - Bauer, Michael
A1  - Kronmüller, Klaus
A1  - Brieger, Peter
A1  - Laux, Gerd
A1  - Bender, Wolfram
A1  - Heuser, Isabella
A1  - Zeiler, Joachim
A1  - Gaebel, Wolfgang
A1  - Schennach-Wolff, Rebecca
A1  - Henkel, Verena
A1  - Seemüller, Florian
SP  - 137
EP  - 149
VL  - 133
IS  - 1-2
N2  - BACKGROUND: Most predictor analyses search for single predictors or rely on data from randomized controlled trials. We aimed at detecting a set of clinical baseline variables for prediction of response and remission in 1014 naturalistically treated inpatients with major depressive episode treated for 53.62±47.5days. METHODS: A three-staged procedure was implemented. First, univariate tests were used for finding associations with baseline variables. Second, logistic regression and third-CART analyses were used to determine predictors of response to inpatient treatment. RESULTS: Presence of suicidality, a higher initial HAMD-21 total score, an episode length<24months, fewer previous hospitalizations, and absence of any ICD-10F4 comorbidity predicted response in 2 different statistical models. Remission was predicted by lower HAMD-21 baseline score, episode length<24months and fewer previous hospitalizations in both models. LIMITATION: Results were assessed by a post-hoc analysis, based on prospectively collected data. No controlled study design. CONCLUSION: Contrary to current beliefs, baseline suicidality might be associated with higher chances for response. In addition, baseline severity might impact outcome depending on which criterion (remission or response) used.<p />  <p>Language: en</p>
LA  - en
SN  - 0165-0327
UR  - http://dx.doi.org/10.1016/j.jad.2011.04.007
ID  - ref1
ER  -