TY  - JOUR
PY  - 1995//
TI  - Control of vascular reactivity
JO  - New horizons
A1  - McCormack, D. G.
SP  - 248
EP  - 256
VL  - 3
IS  - 2
N2  - The two commonly recognized sequelae of acute lung injury (ALI) are pulmonary hypertension and arterial hypoxemia. The mechanism of the pulmonary hypertension is not precisely known, but undoubtedly is contributed to by both vasoactive mediators and pulmonary parenchymal structural changes. The pulmonary circulation is normally tightly controlled such that there is excellent matching of perfusion to ventilation through attenuation of hypoxic pulmonary vasoconstriction (HPV). In ALI, there is an attenuation of HPV and resulting areas of low ventilation/perfusion or shunt. The mechanism behind this abnormal pulmonary vascular contractility in disease is under investigation, but may involve the release of endogenous vasodilator mediators such as nitric oxide.<p /> <p>Language: en</p>
LA  - en
SN  - 1063-7389
UR  - http://dx.doi.org/
ID  - ref1
ER  -