TY  - JOUR
PY  - 2007//
TI  - Fatty Acid Amide Hydrolase: From Characterization to Therapeutics
JO  - Chemistry and biodiversity
A1  - Labar, Geoffray
A1  - Michaux, Catherine
SP  - 1882
EP  - 1902
VL  - 4
IS  - 8
N2  - Fatty acid amide hydrolase (FAAH) is an integral membrane enzyme within the amidase-signature family that terminates the action of several endogenous lipid messengers, including oleamide and the endocannabinoid anandamide. The hydrolysis of such messengers leads to molecules devoid of biological activity, and, therefore, modulates a number of neurobehavioral processes in mammals, including pain, sleep, feeding, and locomotor activity. Investigations into the structure and function of FAAH, its biological and therapeutic implications, as well as a description of different families of FAAH inhibitors are the topic of this review.<p /> 
LA  - 
SN  - 1612-1872
UR  - http://dx.doi.org/10.1002/cbdv.200790157
ID  - ref1
ER  -