TY  - JOUR
PY  - 2008//
TI  - Beyond insulin resistance: Innate immunity in nonalcoholic steatohepatitis
JO  - Hepatology
A1  - Maher, Jacquelyn J.
A1  - Leon, Pablo
A1  - Ryan, James C.
SP  - 670
EP  - 678
VL  - 48
IS  - 2
N2  - Obesity is an inflammatory disorder characterized by heightened activity of the innate immune system. Innate immune activation is central to the development of obesity-related insulin resistance; it also plays an important role in obesity-related tissue damage, such as that seen in atherosclerosis. Recent research has implicated the innate immune system in the pathophysiology of obesity-related liver disease. This review summarizes how innate immune processes, occurring both within and outside the liver, cause not only insulin resistance but also end-organ damage in the form of nonalcoholic fatty liver disease. (HEPATOLOGY 2008;48:670–678.)<p /> 
LA  - 
SN  - 0270-9139
UR  - http://dx.doi.org/10.1002/hep.22399
ID  - ref1
ER  -