TY  - JOUR
PY  - 2008//
TI  - Baicalein stimulates osteoblast differentiation via coordinating activation of MAP kinases and transcription factors
JO  - Journal of cellular biochemistry
A1  - Kim, Jin Mi
A1  - Lee, Su‐Ui
A1  - Kim, Young Sup
A1  - Min, Yong Ki
A1  - Kim, Seong Hwan
SP  - 1906
EP  - 1917
VL  - 104
IS  - 5
N2  - The identification of anabolic agents that directly stimulate bone formation has recently attracted greater interest. Here, baicalein was identified as a natural compound that stimulates the differentiation of mouse osteoblastic MC3T3-E1 subclone 4 cells. Baicalein induced the activation of NF-κB in the initiation stage of osteoblast differentiation, and it activated the MAP kinase/NF-κB signaling pathway and induced the expression of osteoblast differentiation markers in the early stage. In the late stage, baicalein stimulated the calcium deposition with the activation of MAP kinases and AP-1 family members such as Fra-1 and Fra-2. Another transcription factor, NFATc1, was slightly induced by baicalein in the late stage. Thus, baicalein could stimulate the osteoblast differentiation via the activation of complexly coordinated signaling pathways that include MAP kinases and transcription factors such as NF-κB, AP-1, and NFATc1. J. Cell. Biochem. 104: 1906–1917, 2008. © 2008 Wiley-Liss, Inc.<p /> 
LA  - 
SN  - 0730-2312
UR  - http://dx.doi.org/10.1002/jcb.21760
ID  - ref1
ER  -