TY  - JOUR
PY  - 1990//
TI  - The effects of codeine on human aggressive responding
JO  - International clinical psychopharmacology
A1  - Spiga, R.
A1  - Cherek, D. R.
A1  - Roache, John D.
A1  - Cowan, K. A.
SP  - 195
EP  - 204
VL  - 5
IS  - 3
N2  - Ten healthy male research subjects received placebo, 25, 50 and 75 mg/70 kg of codeine in a controlled laboratory setting. During each session subjects had two response options. The non-aggressive response option was maintained by points exchangeable for ten cents. The aggressive response option ostensibly subtracted a point from the subject's fictitious partner. Aggressive responding was engendered by point subtractions attributed to a fictitious partner. Codeine did not significantly alter the frequency of monetarily reinforced, nonaggressive, responding. Aggressive responding was significantly increased at the 50 mg/70 kg dose of codeine. The frequency of aggressive responses during the placebo sessions preceding administration of the first codeine dose were significantly and positively correlated with scores on the Buss-Durkee Hostility Scale. Aggressive responding increased for four of five subjects scoring below the median on the Buss-Durkee Hostility Scale at the 50 mg/70 kg dose; while administration of 50 mg/70 kg increased aggressive responding of one subject who scored above the median. Aggressive responding for both groups of subjects was unaffected by the 75 mg/70 kg dose.<p /> <p>Language: en</p>
LA  - en
SN  - 0268-1315
UR  - http://dx.doi.org/
ID  - ref1
ER  -