TY  - JOUR
PY  - 2007//
TI  - Consensus report on impulsive aggression as a symptom across diagnostic categories in child psychiatry: implications for medication studies
JO  - Journal of the American Academy of Child and Adolescent Psychiatry
A1  - Jensen, Peter S.
A1  - Youngstrom, Eric A.
A1  - Steiner, Hans
A1  - Findling, Robert L.
A1  - Meyer, Roger E.
A1  - Malone, Richard P.
A1  - Carlson, Gabrielle A.
A1  - Coccaro, Emil F.
A1  - Aman, Michael G.
A1  - Blair, James
A1  - Dougherty, Donald
A1  - Ferris, Craig
A1  - Flynn, Laurie
A1  - Green, Evelyn
A1  - Hoagwood, Kimberly
A1  - Hutchinson, Janice
A1  - Laughren, Tom
A1  - Leve, Leslie D.
A1  - Novins, Douglas K.
A1  - Vitiello, Benedetto
SP  - 309
EP  - 322
VL  - 46
IS  - 3
N2  - OBJECTIVE: To determine whether impulsive aggression (IA) is a meaningful clinical construct and to ascertain whether it is sufficiently similar across diagnostic categories, such that parallel studies across disorders might constitute appropriate evidence for pursuing indications. If so, how should IA be assessed, pharmacological studies designed, and ethical issues addressed? METHOD: Experts from key stakeholder communities, including academic clinicians, researchers, practicing clinicians, U.S. Food and Drug Administration, National Institute of Mental Health, industry sponsors, and patient and family advocates, met for a 2-day consensus conference on November 4 and 5, 2004. After evaluating summary presentations on current research evidence, participants were assigned to three workgroups, examined core issues, and generated consensus guidelines in their areas. Workgroup recommendations were discussed by the whole group to reach consensus, and then further iterated and condensed into this report postconference by the authors. RESULTS: Conference participants agreed that IA is a substantial public health and clinical concern, constitutes a key therapeutic target across multiple disorders, and can be measured with sufficient precision that pharmacological studies are warranted. Additional areas of consensus concerned types of measures, optimal study designs, and ethical imperatives. CONCLUSION: Derived from scientific evidence and clinical experience, these consensus-driven recommendations can guide the design of future studies.<p /> <p>Language: en</p>
LA  - en
SN  - 0890-8567
UR  - http://dx.doi.org/10.1097/chi.0b013e31802f1454
ID  - ref1
ER  -