TY  - JOUR
PY  - 2001//
TI  - Differential effect of Fyn tyrosine kinase deletion on offensive and defensive aggression
JO  - Behavioural brain research
A1  - Miyakawa, T.
A1  - Yagi, T.
A1  - Takao, K.
A1  - Niki, H.
SP  - 51
EP  - 56
VL  - 122
IS  - 1
N2  - Fyn tyrosine kinase is highly expressed in the limbic system and mice lacking Fyn tyrosine kinase showed increased fearfulness in a variety of tests for anxiety-related behaviors. To investigate the possible role of Fyn tyrosine kinase in aggression, we assessed the aggressive behaviors of the mice lacking the Fyn tyrosine kinase using the resident-intruder and restraint-induced target biting paradigms. The percentage of Fyn-deficient mice that attacked an inanimate target in a restraint tube was higher than that of the control mice. On the contrary, in the resident-intruder paradigm, the percentage of Fyn-deficient mice that attacked the intruder was lower and the Fyn-deficient mice showed a longer latency to attack an intruder. These results suggest a distinct role of Fyn tyrosine kinase in enhancing the offensive aggression and decreasing the defensive aggression. A possible influence of anxiety-phenotype of the Fyn-deficient mice on their abnormal aggressive behavior was discussed.<p /> <p>Language: en</p>
LA  - en
SN  - 0166-4328
UR  - http://dx.doi.org/
ID  - ref1
ER  -