TY  - JOUR
PY  - 2001//
TI  - CSF studies in violent offenders. II. Blood-brain barrier dysfunction without concurrent inflammation or structure degeneration
JO  - Journal of neural transmission
A1  - Soderstrom, H.
A1  - Blennow, K.
A1  - Manhem, A.
A1  - Forsman, A.
SP  - 879
EP  - 886
VL  - 108
IS  - 7
N2  - Cerebral dysfunction without corresponding structural pathology has been reported in brain imaging studies of violent offenders. Biochemical markers in the CSF reflect various types of CNS pathology, such as blood-brain barrier dysfunction (CSF/S albumin ratio), infectious or inflammatory processes (IgG and IgM indices), neuronal or axonal degeneration (CSF-tau protein) and synaptic de- or regeneration (CSF-growth associated protein-43 (GAP-43)). We compared these CSF markers in 19 non-psychotic perpetrators of severe violent crimes undergoing pretrial forensic psychiatric investigation and 19 age- and sex-matched controls. Index subjects had significantly higher albumin ratios (p = 0.002), indicating abnormal vascular permeability as part of the complex CNS dysfunction previously reported in violent offenders. Axis I disorders, including substance abuse or current medication, did not explain this finding. Since Ig-indices, CSF-tau protein or CSF-GAP-43 were not increased, there was no support for inflammation or neuronal/synaptic degeneration as etiological factors to CNS dysfunction in this category of subjects.<p /> <p>Language: en</p>
LA  - en
SN  - 0300-9564
UR  - http://dx.doi.org/
ID  - ref1
ER  -