TY  - JOUR
PY  - 2009//
TI  - Childhood neglect and abuse as predictors of antidepressant response in adult depression
JO  - Depression and anxiety
A1  - Johnstone, Jeanette M.
A1  - Luty, Suzanne E.
A1  - Carter, Janet D.
A1  - Mulder, Roger T.
A1  - Frampton, Christopher M. A.
A1  - Joyce, Peter R.
SP  - 711
EP  - 717
VL  - 26
IS  - 8
N2  - BACKGROUND: Childhood neglect and abuse are recognized as risk factors for depression, but are not often studied as predictors of treatment response in depression. METHODS: Clinically depressed outpatients (n=195) were asked about childhood experiences before beginning a randomized antidepressant trial with either fluoxetine or nortriptyline. Three treatment outcomes were measured: Adequate trial, six-week response and two months sustained recovery. RESULTS: Patients reporting low paternal care (paternal neglect), as measured by the Parental Bonding Instrument (PBI), were less likely to complete an adequate six-week trial of medication. Patients who reported high maternal protection (maternal overprotection) on the PBI had poorer treatment response in the short-term at six weeks, and longer term, for two months of sustained recovery. However, abuse, whether sexual, physical, or psychological in nature, did not predict treatment response. CONCLUSIONS: The experience of having a neglectful father or an overprotective mother was more predictive of response to treatment for depression than abuse, suggesting that the quality of ongoing intra-familial relationships has a greater impact on treatment outcomes for depression than experiences of discrete abuse in childhood.<p /> <p>Language: en</p>
LA  - en
SN  - 1091-4269
UR  - http://dx.doi.org/10.1002/da.20590
ID  - ref1
ER  -