TY  - JOUR
PY  - 2005//
TI  - Pervasive social deficits, but normal parturition, in oxytocin receptor-deficient mice
JO  - Proceedings of the National Academy of Sciences of the United States of America
A1  - Takayanagi, Yuki
A1  - Yoshida, Masahide
A1  - Bielsky, Isadora F.
A1  - Ross, Heather E.
A1  - Kawamata, Masaki
A1  - Onaka, Tatsushi
A1  - Yanagisawa, Teruyuki
A1  - Kimura, Tadashi
A1  - Matzuk, Martin M.
A1  - Young, Larry J.
A1  - Nishimori, Katsuhiko
SP  - 16096
EP  - 16101
VL  - 102
IS  - 44
N2  - The oxytocin receptor (OXTR) and its ligand, oxytocin (OXT), regulate reproductive physiology (i.e., parturition and lactation) and sociosexual behaviors. To define the essential functions of OXTR, we generated mice with a null mutation in the Oxtr gene (Oxtr(-/-)) and compared them with OXT-deficient (Oxt(-/-)) mice. Oxtr(-/-) mice were viable and had no obvious deficits in fertility or reproductive behavior. Oxtr(-/-) dams exhibited normal parturition but demonstrated defects in lactation and maternal nurturing. Infant Oxtr(-/-) males emitted fewer ultrasonic vocalizations than wild-type littermates in response to social isolation. Adult Oxtr(-/-) males also showed deficits in social discrimination and elevated aggressive behavior. Ligand Oxt(-/-) males from Oxt(-/-) dams, but not from Oxt(+/-) dams, showed similar high levels of aggression. These data suggest a developmental role for the OXT/OXTR system in shaping adult aggressive behavior. Our studies demonstrate that OXTR plays a critical role in regulating several aspects of social behavior and may have important implications for developmental psychiatric disorders characterized by deficits in social behavior.<p /> <p>Language: en</p>
LA  - en
SN  - 0027-8424
UR  - http://dx.doi.org/10.1073/pnas.0505312102
ID  - ref1
ER  -