TY  - JOUR
PY  - 2007//
TI  - Behavioral correlates of GABAergic disruption in Alzheimer's disease
JO  - International psychogeriatrics / IPA
A1  - Lanctôt, Krista L.
A1  - Herrmann, Nathan
A1  - Rothenburg, Lana S.
A1  - Eryavec, Goran
SP  - 151
EP  - 158
VL  - 19
IS  - 1
N2  - BACKGROUND: Losses of gamma-aminobutyric acid (GABA) have been variably demonstrated in Alzheimer's disease (AD) and may be related to the presence of behavioral and psychological symptoms of dementia (BPSD) in AD. Our objective was to assess the relationship between plasma GABA (pGABA) levels and specific BPSD in patients with severe AD. METHODS: pGABA levels and BPSD were measured in 14 institutionalized AD patients (8M/6F, mean age +/- S.D. = 85.6 +/- 4.5 years) with severe cognitive impairment (Mini-mental State Examination score = 4.5 +/- 4.6) and prominent behavioral disturbances (Neuropsychiatric Inventory (NPI) score = 33.4 +/- 23.6). RESULTS: pGABA was positively correlated with depression and apathy scores on the NPI and negatively correlated with age. Apathy and age were independent predictors of pGABA levels. CONCLUSIONS: The final stages of AD are associated with GABAergic changes, which may contribute to depression and apathy in AD.<p /> <p>Language: en</p>
LA  - en
SN  - 1041-6102
UR  - http://dx.doi.org/10.1017/S1041610206003899
ID  - ref1
ER  -