TY  - JOUR
PY  - 1995//
TI  - Enhanced vulnerability to secondary ischemic insults after experimental traumatic brain injury
JO  - New horizons
A1  - DeWitt, D. S.
A1  - Jenkins, L. W.
A1  - Prough, D. S.
SP  - 376
EP  - 383
VL  - 3
IS  - 3
N2  - Both experimental traumatic brain injury and clinical traumatic brain injury appear to render the brain more vulnerable to a second ischemic insult. The mechanisms of enhanced vulnerability to subsequent ischemia appear to include a reduced ability to increase cerebral blood flow in response to hypotension, hypoxemia, or acute anemia and increased tissue sensitivity to ischemia. Although numerous mediators may be involved in increased tissue sensitivity, those that particularly merit investigation include oxygen free radicals, glutamate, arachidonate metabolites, calcium ions, and protein kinase C.<p /> <p>Language: en</p>
LA  - en
SN  - 1063-7389
UR  - http://dx.doi.org/
ID  - ref1
ER  -