TY  - JOUR
PY  - 1997//
TI  - The relationship between smooth pursuit performance, motion perception and sustained visual attention in patients with schizophrenia and normal controls
JO  - Psychological medicine
A1  - Stuve, T. A.
A1  - Friedman, L.
A1  - Jesberger, J. A.
A1  - Gilmore, G. C.
A1  - Strauss, M. E.
A1  - Meltzer, H. Y.
SP  - 143
EP  - 152
VL  - 27
IS  - 1
N2  - BACKGROUND: In this study, we tested the hypothesis that low smooth pursuit gain in schizophrenia is related to an abnormality in motion perception. METHODS: The subjects were 19 schizophrenics treated with clozapine and 19 controls. In addition to smooth pursuit and motion perception paradigms, sustained attention was also assessed using a continuous performance task (CPT). RESULTS: In the patient group, there was a statistically significant negative correlation between smooth pursuit gain and motion perception threshold (r = -0.60, P < 0.01). This relationship was not secondary to attention deficits as assessed by the CPT. CONCLUSIONS: Our results are consistent with the notion that the smooth pursuit gain deficit is related to a deficit in motion perception rather than in attention. Brain area V5 (also referred to as "MT' in macaque), located in the parieto-occipital region, is known to be critically important both for motion perception and gain. Thus, our results point to an abnormality in this area in schizophrenia.<p /> <p>Language: en</p>
LA  - en
SN  - 0033-2917
UR  - http://dx.doi.org/
ID  - ref1
ER  -