TY  - JOUR
PY  - 1995//
TI  - Melatonin and cortisol assessment of circadian shifts in astronauts before flight
JO  - Journal of Pineal Research
A1  - Whitson, P. A.
A1  - Putcha, L.
A1  - Chen, Y. M.
A1  - Baker, Elina
SP  - 141
EP  - 147
VL  - 18
IS  - 3
N2  - Melatonin and cortisol were measured in saliva and urine samples to assess the effectiveness of a 7-day protocol combining bright-light exposure with sleep shifting in eliciting a 12-hr phase-shift delay in eight U.S. Space Shuttle astronauts before launch. Baseline acrophases for 15 control subjects with normal sleep-wake cycles were as follows: cortisol (saliva) at 0700 (0730 in urine); melatonin (saliva) at 0130 (6-hydroxymelatonin sulfate at 0230 in urine). Acrophases of the astronaut group fell within 2.5 hr of these values before the treatment protocols were begun. During the bright-light and sleep-shifting treatments, both absolute melatonin production and melatonin rhythmicity were diminished during the first 3 treatment days; total daily cortisol levels remained constant throughout the treatment. By the fourth to sixth day of the 7-day protocol, seven of the eight crew members showed phase delays in all four measures that fell within 2 hr of the expected 11- to 12-hr shift. Although cortisol and melatonin rhythms each corresponded with the phase shift, the rhythms in these two hormones did not correspond with each other during the transition.<p /> <p>Language: en</p>
LA  - en
SN  - 0742-3098
UR  - http://dx.doi.org/
ID  - ref1
ER  -