TY  - JOUR
PY  - 2006//
TI  - Poor response inhibition as a predictor of problem drinking and illicit drug use in adolescents at risk for alcoholism and other substance use disorders
JO  - Journal of the American Academy of Child and Adolescent Psychiatry
A1  - Zucker, Robert A.
A1  - Fitzgerald, Hiram E.
A1  - Puttler, Leon I.
A1  - Jester, Jennifer M.
A1  - Martel, Michelle M.
A1  - Adams, K. M.
A1  - Glass, Jennifer M.
A1  - Wong, Mamie Mee
A1  - Nigg, Joel T.
SP  - 468
EP  - 475
VL  - 45
IS  - 4
N2  - OBJECTIVE: To evaluate the predictive power of executive functions, in particular, response inhibition, in relation to alcohol-related problems and illicit drug use in adolescence. METHOD: A total of 498 children from 275 families from a longitudinal high-risk study completed executive function measures in early and late adolescence and lifetime drinking and drug-related ratings at multiple time points including late adolescence (ages 15-17). Multi-informant measures of attention-deficit/hyperactivity disorder and conduct disorder were obtained in early childhood (ages 3-5), middle childhood, and adolescence. RESULTS: In multilevel models, poor response inhibition predicted aggregate alcohol-related problems, the number of illicit drugs used, and comorbid alcohol and drug use (but not the number of drug-related problems), independently of IQ, parental alcoholism and antisocial personality disorder, child attention-deficit/hyperactivity disorder and conduct symptoms, or age. Multivariate models explained 8% to 20% of residual variance in outcome scores. The incremental predictive power of response inhibition was modest, explaining about 1% of the variance in most outcomes, but more than 9% of the residual variance in problem outcomes within the highest risk families. Other measured executive functions did not independently predict substance use onset. CONCLUSION: Models of alcoholism and other drug risks that invoke executive functions may benefit from specifying response inhibition as an incremental component.<p />  <p>Language: en</p>
LA  - en
SN  - 0890-8567
UR  - http://dx.doi.org/10.1097/01.chi.0000199028.76452.a9
ID  - ref1
ER  -