TY  - JOUR
PY  - 2002//
TI  - Pulmonary immunohistochemistry and serum levels of a surfactant-associated protein A in fatal drowning
JO  - Legal medicine (Elsevier)
A1  - Zhu, Bao-Li
A1  - Ishida, Kaori
A1  - Quan, Linda
A1  - Li, Dong-Ri
A1  - Taniguchi, Mari
A1  - Fujita, Masaki Q.
A1  - Maeda, Hitoshi
A1  - Tsuji, Tsutomu
SP  - 1
EP  - 6
VL  - 4
IS  - 1
N2  - To evaluate the immunohistochemical distribution and serum levels of a pulmonary surfactant-associated protein A (SP-A) in fatal drowning with regard to the pulmonary alveolar injury, 53 autopsy cases were investigated. SP-A was membranously or linearly demonstrated in varying intensities on the intra-alveolar interior surface and on the interface of the intra-alveolar effusion. A high score of intra-alveolar aggregates of SP-A was significantly more frequently observed in freshwater than saltwater drowning. The left/right ratios of cardiac blood SP-A level were significantly high both in fresh- and saltwater drowning, showing no relationship to aggregated SP-A scores. Immunohistochemical score and serum level of SP-A were independent of the lung weight or pleural effusion. These observations suggest a partial difference of pulmonary pathophysiology depending on the immersion medium in fatal drowning.<p /> <p>Language: en</p>
LA  - en
SN  - 1344-6223
UR  - http://dx.doi.org/
ID  - ref1
ER  -