TY  - JOUR
PY  - 1998//
TI  - The determination in the blood of the enzyme neuron-specific enolase in children with acute encephalopathies: the prognostic value in neurological sequelae
JO  - Anales Espanoles de Pediatria
A1  - Verdú Pérez, A.
A1  - Garde Morales, T.
A1  - Martínez Campos, M.
A1  - Rinaudo Zanirato, R.
A1  - Alonso Martin, J. A.
SP  - 17
EP  - 20
VL  - 48
IS  - 1
N2  - OBJECTIVE: The objective of this study was to evaluate if there is a correlation between blood levels of the enzyme neuron-specific enolase in children with non-traumatic acute encephalopathies with severe alterations in consciousness and the neurological sequellae. PATIENTS AND METHODS: Neuron-specific enolase (EC 4.2.1.11) activity in plasma was measured by radioimmunoassay in 9 children aged 7 months to 5 years, who suffered acute encephalopathy and coma of non-traumatic origin. The etiology was acute viral encephalitis (n = 4), near drowning (n = 2), shock (n = 2) and cardiac arrest (n = 1). Blood samples were obtained between 24 and 72 hours after the onset of encephalopathy. The neurological status was evaluated 18 months after the onset of encephalopathy in the 8 surviving patients (1 patient with brain death criteria died in the acute stage). RESULTS: Enzyme activities were significantly higher in the children who showed neurological sequelae (median 68.9 ng/ml, range 35.0-95.6, n = 4) than in those who did not present neurological abnormalities (median 15.8 ng/ml, range 9.7-18.7, n = 5), with p < 0.05. No differences were found between the latter and the control group (median 7.7 ng/ml, range 4.1-12.7, n = 10). CONCLUSIONS: It appears that the presence of elevated neuron-specific enolase in blood is predictive of neurological outcome in children with acute encephalopathies of non-traumatic origin.<p /> <p>Language: es</p>
LA  - es
SN  - 0302-4342
UR  - http://dx.doi.org/
ID  - ref1
ER  -