TY  - JOUR
PY  - 2006//
TI  - Recurrent intraparenchimal haemorrhages in a patient with cerebral amyloidotic angiopathy: description of one autopsy case
JO  - Pathologica
A1  - Gallo, C.
A1  - Orlassino, R.
A1  - Vineis, C.
SP  - 44
EP  - 47
VL  - 98
IS  - 1
N2  - Cerebral amyloidotic angiopathy represents the most frequent cause of lobar haematoma in young patients and represents 5-10% of the non-traumatic cerebral haemorrhages. In the present work, we describe one autoptic case of recurrent cerebral haemorrhages in a 58-year-old woman. Macroscopically in the brain multiple haemorragic areas were present in the right frontal pole, right frontal and temporo-parietal lobes with homolateral ventricular inundation. The histological, histochemical, immunohistochemical, ultrastructural and biomolecular investigations confirmed the presence of amyloid deposits in the middle-size and little-size cerebral arteries. We report, moreover, a novel mutation (Leu705Val) within the Abeta sequence of a AbetaPP in a family with autosomal dominant, recurrent intracerebral hemorrhages beginning in the sixth decade of life.<p /> <p>Language: it</p>
LA  - it
SN  - 0031-2983
UR  - http://dx.doi.org/
ID  - ref1
ER  -