TY  - JOUR
PY  - 1996//
TI  - GTP gamma S and forskolin-stimulated adenylyl cyclase activity in post-mortem brain from depressed suicides and controls
JO  - Molecular psychiatry
A1  - Lowther, S.
A1  - Crompton, M. R.
A1  - Katona, C. L.
A1  - Horton, R. W.
SP  - 470
EP  - 477
VL  - 1
IS  - 6
N2  - We have measured basal, guanosine 5'-O-(3-thiotriphosphate) (GTP gamma S) and forskolin-stimulated adenylyl cyclase activity in samples of frontal and parietal cortex obtained at post-mortem from suicides, with a firm retrospective diagnosis of depression. The suicides were divided into those free of antidepressants and those receiving antidepressants. Each suicide was individually compared to a gender and age-matched control. Although we found no significant differences in adenylyl cyclase activity between controls and either antidepressant-free or antidepressant-treated suicides, there was a trend for lower stimulated adenylyl cyclase activity in suicides.<p /> <p>Language: en</p>
LA  - en
SN  - 1359-4184
UR  - http://dx.doi.org/
ID  - ref1
ER  -