TY  - JOUR
PY  - 2000//
TI  - Valproic acid intoxication identified by 1H and 1H-(13)C correlated NMR spectroscopy of urine samples
JO  - Magma
A1  - Azaroual, N.
A1  - Imbenotte, M.
A1  - Cartigny, B.
A1  - Leclerc, F.
A1  - Vallée, L.
A1  - Lhermitte, M.
A1  - Vermeersch, G.
SP  - 177
EP  - 182
VL  - 10
IS  - 3
N2  - Analysis of biological fluids by proton and carbon nuclear magnetic resonance spectroscopy (1H and 13C NMR) is a promising tool in clinical biology. We used this method for rapid toxicological screening in the case of two suicide attempts. For each case, a urine sample was analysed at 300 MHz by 1D and 2D sequences (TOCSY and HMBC) in a short experimental time. Quantification was performed by peak integration on the 1D 1H NMR spectrum. For the two patients, results showed the same resonances of the major metabolite, valproyl-O-glucuronide at concentrations of 121 and 44 mmol/l.<p /> <p>Language: en</p>
LA  - en
SN  - 0968-5243
UR  - http://dx.doi.org/
ID  - ref1
ER  -