TY  - JOUR
PY  - 1997//
TI  - Beta-adrenoceptors in human pineal glands are unaltered in depressed suicides
JO  - Journal of psychopharmacology
A1  - De Paermentier, F.
A1  - Lowther, S.
A1  - Crompton, M. R.
A1  - Katona, C. L.
A1  - Horton, R. W.
SP  - 295
EP  - 299
VL  - 11
IS  - 4
N2  - We have measured beta-adrenoceptor binding in pineal glands obtained at post mortem from suicides with a firm retrospective diagnosis of depression, and from age and gender-matched controls. In both antidepressant-free and antidepressant-treated suicides there were no significant differences in the number or affinity of beta-adrenoceptors compared to controls. Within the total group of subjects we found no variation in beta-adrenoceptor binding in relation to time of death or season of death. There was a significant negative correlation between the number of beta-adrenoceptors and age in controls, but not in suicides. These results suggest that pineal beta-adrenoceptors are not altered either in depression or as a result of antidepressant treatment.<p /> <p>Language: en</p>
LA  - en
SN  - 0269-8811
UR  - http://dx.doi.org/
ID  - ref1
ER  -