TY  - JOUR
PY  - 1997//
TI  - HPLC-DAD and HPLC-MS findings in fatality involving (Z)-cis-clopenthixol (zuclopenthixol)
JO  - Journal of analytical toxicology
A1  - Tracqui, A.
A1  - Kintz, P.
A1  - Cirimele, V.
A1  - Berthault, F.
A1  - Mangin, Patrice
A1  - Ludes, Bertrand
SP  - 314
EP  - 318
VL  - 21
IS  - 4
N2  - A fatality that was due to massive ingestion of the thioxanthene neuroleptic (Z)-cis-clopenthixol (zuclopenthixol, Z-CPT) is described. The total toxicological screening and the quantitation of both the ingested drugs and its inactive isomer (E)-trans-clopenthixol (E-CPT, produced by in vivo isomerization) in postmortem fluids and viscerae were produced by high-performance liquid chromatography (HPLC)-diode array detection. Drug confirmation was carried out by HPLC-mass spectrometry with an ionspray interface. Although death occurred 40 h after the drug intake, postmortem blood concentrations were 391 and 275 mg/mL for Z-CPT and E-CPT, respectively (50 to 100 times the usual therapeutic values). The cause of death was suicide, and the manner was acute neuroleptic overdosage.<p /> <p>Language: en</p>
LA  - en
SN  - 0146-4760
UR  - http://dx.doi.org/
ID  - ref1
ER  -