TY  - JOUR
PY  - 1998//
TI  - 3H imipramine binding in brain samples from depressed suicides and controls: 5-HT uptake sites compared with sites defined by desmethylimipramine
JO  - Journal of affective disorders
A1  - Lawrence, K. M.
A1  - Kanagasundaram, M.
A1  - Lowther, S.
A1  - Katona, C. L.
A1  - Crompton, M. R.
A1  - Horton, R. W.
SP  - 105
EP  - 112
VL  - 47
IS  - 1-3
N2  - Using desmethylimipramine (DMI) defined and Na+ dependent [3H]imipramine binding, we have examined both 5-HT uptake sites and sites unrelated to 5-HT uptake, in frontal cortex, putamen and substantia nigra of suicides with a firm retrospective diagnosis of depression and matched controls. No differences were seen between antidepressant-free suicides and controls, although [3H]imipramine binding sites were significantly lower in putamen of the subgroup of non-violent suicides. The number of DMI defined [3H]imipramine binding sites was also significantly lower in putamen of antidepressant-treated suicides.<p /> <p>Language: en</p>
LA  - en
SN  - 0165-0327
UR  - http://dx.doi.org/
ID  - ref1
ER  -