TY  - JOUR
PY  - 2002//
TI  - Suicide risk in patients with anxiety disorders: a meta-analysis of the FDA database
JO  - Journal of affective disorders
A1  - Khan, Arif
A1  - Leventhal, Robyn M.
A1  - Khan, Shirin
A1  - Brown, Walter A.
SP  - 183
EP  - 190
VL  - 68
IS  - 2-3
N2  - BACKGROUND: Previous reports of suicide risk in patients with anxiety disorders have been inconsistent. METHODS: Using the FDA database, we assessed suicide and suicide attempt risk among patients, participating in recent clinical trials evaluating new anti-anxiety medications, with diagnosis of panic disorder (PD), social anxiety disorder or social phobia (SP), generalized anxiety disorder (GAD), post traumatic stress disorder (PTSD), and obsessive compulsive disorder (OCD). RESULTS: Overall, among 20076 participating anxious patients, 12 committed suicide and 28 attempted suicide. The annual suicide risk rate was 193/100000 patients and annual suicide attempt risk was 1350/100000 patients. LIMITATIONS: Clinical trial data have limited applicability to clinical practice. Participants in clinical trials are a highly selected, nonrepresentative sample of the clinical population. A number of patients never complete clinical trials and thus data are based on a limited sub-sample. These trials were not primarily designed to assess suicide risk. CONCLUSIONS: Suicide risk in patients with anxiety disorders is higher than previously thought. Patients with anxiety disorders warrant explicit evaluation for suicide risk.<p /> <p>Language: en</p>
LA  - en
SN  - 0165-0327
UR  - http://dx.doi.org/
ID  - ref1
ER  -