TY  - JOUR
PY  - 2011//
TI  - Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder: a preliminary report
JO  - Journal of psychopharmacology
A1  - Crippa, José Alexandre S.
A1  - Nogueira Derenusson, Guilherme
A1  - Borduqui Ferrari, Thiago
A1  - Wichert-Ana, Lauro
A1  - Duran, Fábio LS
A1  - Martin-Santos, Rocio
A1  - Vinícius Simões, Marcus
A1  - Bhattacharyya, Sagnik
A1  - Fusar-Poli, Paolo
A1  - Atakan, Zerrin
A1  - Santos Filho, Alaor
A1  - Freitas-Ferrari, Maria Cecília
A1  - McGuire, Philip K.
A1  - Zuardi, Antonio Waldo
A1  - Busatto, Geraldo F.
A1  - Hallak, Jaime Eduardo Cecílio
SP  - 121
EP  - 130
VL  - 25
IS  - 1
N2  - Animal and human studies indicate that cannabidiol (CBD), a major constituent of cannabis, has anxiolytic properties. However, no study to date has investigated the effects of this compound on human pathological anxiety and its underlying brain mechanisms. The aim of the present study was to investigate this in patients with generalized social anxiety disorder (SAD) using functional neuroimaging. Regional cerebral blood flow (rCBF) at rest was measured twice using (99m)Tc-ECD SPECT in 10 treatment-naïve patients with SAD. In the first session, subjects were given an oral dose of CBD (400 mg) or placebo, in a double-blind procedure. In the second session, the same procedure was performed using the drug that had not been administered in the previous session. Within-subject between-condition rCBF comparisons were performed using statistical parametric mapping. Relative to placebo, CBD was associated with significantly decreased subjective anxiety (p < 0.001), reduced ECD uptake in the left parahippocampal gyrus, hippocampus, and inferior temporal gyrus (p < 0.001, uncorrected), and increased ECD uptake in the right posterior cingulate gyrus (p < 0.001, uncorrected). These results suggest that CBD reduces anxiety in SAD and that this is related to its effects on activity in limbic and paralimbic brain areas.<p /> 
LA  - 
SN  - 0269-8811
UR  - http://dx.doi.org/10.1177/0269881110379283
ID  - ref1
ER  -