TY  - JOUR
PY  - 2010//
TI  - Influence of gender and menopausal status on antidepressant treatment response in depressed inpatients
JO  - Journal of psychopharmacology
A1  - Vermeiden, M.
A1  - van den Broek, WW
A1  - Mulder, Pgh
A1  - Birkenhäger, TK
SP  - 497
EP  - 502
VL  - 24
IS  - 4
N2  - The present study investigated the influence of gender and menopausal status on treatment response in depressed inpatients, treated with either imipramine or fluvoxamine. The patients were divided into three groups: men, premenopausal women and postmenopausal women. A multivariate analysis was performed using the difference in Hamilton score (pretreatment — post-treatment) for imipramine and fluvoxamine as dependent variable. The following independent variables were used: the baseline Hamilton score, the antidepressant used, the gender-group and the interaction between the type of antidepressant and gender. In total, 138 patients with a DSM IV diagnosis of depressive disorder were analysed. Men responded more favorably to imipramine (B = 7.12, P = 0.005). Premenopausal women had a better response rate to fluvoxamine than men (B = −8.66, P = 0.027). In depressed inpatients, men respond more favorably to imipramine than to fluvoxamine. Premenopausal women respond more frequently to fluvoxamine than men.<p /> 
LA  - 
SN  - 0269-8811
UR  - http://dx.doi.org/10.1177/0269881109105137
ID  - ref1
ER  -