TY  - JOUR
PY  - 2010//
TI  - Sleep state switching
JO  - Neuron
A1  - Saper, Clifford B.
A1  - Fuller, Patrick M.
A1  - Pedersen, Nigel P.
A1  - Lu, Jun
A1  - Scammell, Thomas E.
SP  - 1023
EP  - 1042
VL  - 68
IS  - 6
N2  - We take for granted the ability to fall asleep or to snap out of sleep into wakefulness, but these changes in behavioral state require specific switching mechanisms in the brain that allow well-defined state transitions. In this review, we examine the basic circuitry underlying the regulation of sleep and wakefulness and discuss a theoretical framework wherein the interactions between reciprocal neuronal circuits enable relatively rapid and complete state transitions. We also review how homeostatic, circadian, and allostatic drives help regulate sleep state switching and discuss how breakdown of the switching mechanism may contribute to sleep disorders such as narcolepsy.<p />  <p>Language: en</p>
LA  - en
SN  - 0896-6273
UR  - http://dx.doi.org/10.1016/j.neuron.2010.11.032
ID  - ref1
ER  -