TY  - JOUR
PY  - 2011//
TI  - Tarka(R) overdose in a young child
JO  - Human and experimental toxicology
A1  - Dogan, Murat
A1  - Basaranoglu, Murat
A1  - Peker, Erdal
A1  - Akbayram, Sinan
A1  - Sahin, Musa
A1  - Uner, Abdurrahman
A1  - Caksen, Huseyin
SP  - 1392
EP  - 1398
VL  - 30
IS  - 9
N2  - Tarka® is a combination antihypertensive medication composed of verapamil hydrochloride and trandolapril. A 3.5-year-old female was brought to our hospital due to a sleepy condition 7 hours after an accidental ingestion of six tablets of Tarka® containing 240 mg verapamil hydrochloride and 4 mg trandolapril in each tablet. Five hours after hospitalization, her condition deteriorated and arterial pressure progressively decreased despite the treatment. Finally, a temporary pacemaker was implanted, after which the vital findings began to return to normal values. The pacemaker was removed 13 hours after implantation as normal heart rhythm was observed. There are no reports of intoxication with fixed-dose combination products, especially Tarka®, in young children in the literature. Therefore, we believe that our report can provide an insight on the toxic dose of this drug in younger children. Clinicians should keep in mind that lethargy can be the first symptom of a possible clinical deterioration, even in normotensive and normorhythmic individuals.<p />  <p>Language: en</p>
LA  - en
SN  - 0960-3271
UR  - http://dx.doi.org/10.1177/0960327110389834
ID  - ref1
ER  -