TY  - JOUR
PY  - 2011//
TI  - Defective Adaption of Erythrocytes During Acute Hypoxia Injury in an Elderly Population
JO  - Journals of gerontology. Series A: Biological sciences and medical sciences
A1  - de Gonzalo-Calvo, David
A1  - Neitzert, Kim
A1  - Fernández, María
A1  - Vega-Naredo, Ignacio
A1  - Caballero, Beatriz
A1  - García-Macia, Marina
A1  - Suárez, Francisco Manuel
A1  - Rodríguez-Colunga, María Josefa
A1  - Solano, Juan José
A1  - Coto-Montes, Ana
SP  - 376
EP  - 384
VL  - 66
IS  - 4
N2  - The present study investigated the changes in several erythrocyte oxidative stress biomarkers in hypoxic elderly individuals to analyze the deleterious effects of low oxyhemoglobin saturation in an elderly population. We collected blood samples from one normoxic middle-aged group and two groups composed of individuals older than 75 years of age: one normoxic group and one hypoxic group. Aging appeared to provoke a defective erythrocyte antioxidant defense associated with increased oxidative damage in the elderly population. Acute hypoxia activated an insufficient antioxidant defense response as suggested by the oxidative damage observed. The oxidative imbalance presented in older participants and increased in hypoxia participants had a direct effect on glyceraldehyde-3-phosphate dehydrogenase cell distribution. Oxidative stress levels altered Band 3 protein and mediated caspase-3 activation in erythrocyte from the aged group although it was not extended to hypoxic individuals. Therefore, aged participants appeared to activate an insufficient antioxidant response against hypoxia-related oxidative stress.<p />  <p>Language: en</p>
LA  - en
SN  - 1079-5006
UR  - http://dx.doi.org/10.1093/gerona/glq204
ID  - ref1
ER  -