TY  - JOUR
PY  - 2011//
TI  - Neuropeptide S receptor deficiency modulates spontaneous locomotor activity and the acoustic startle response
JO  - Behavioural brain research
A1  - Fendt, Markus
A1  - Buchi, Mélanie
A1  - Bürki, Hugo
A1  - Imobersteg, Stefan
A1  - Ricoux, Bérangère
A1  - Suply, Thomas
A1  - Sailer, Andreas W.
SP  - 1
EP  - 9
VL  - 217
IS  - 1
N2  - The present study investigated the phenotype of heterozygous and homozygous neuropeptide S receptor (Npsr) deficient C57BL/6 mice in NPS- and cocaine induced hyperactivity, spontaneous and reactive locomotor activity, elevated plus maze, conditioned fear, and prepulse inhibition of the acoustic startle response. In Npsr-deficient mice, a strong reduction of spontaneous locomotor activity and of the startle magnitude was observed; heterozygous mice had an intermediate phenotype. In the other experiments, Npsr deficiency leads to no or only a very modest phenotype. These results support an important role of neuropeptide S in regulating locomotor activity.<p />  <p>Language: en</p>
LA  - en
SN  - 0166-4328
UR  - http://dx.doi.org/10.1016/j.bbr.2010.09.022
ID  - ref1
ER  -