TY  - JOUR
PY  - 2011//
TI  - Acute psychomotor, memory and subjective effects of MDMA and THC co-administration over time in healthy volunteers
JO  - Journal of psychopharmacology
A1  - Dumont, Gjh
A1  - Van Hasselt, Jgc
A1  - de Kam, M.
A1  - van Gerven, Jma
A1  - Touw, Dj
A1  - Buitelaar, Jan
A1  - Verkes, Robbert-Jan
SP  - 478
EP  - 489
VL  - 25
IS  - 4
N2  - In Western societies a considerable percentage of young people expose themselves to the combination of 3,4-methylenedioxymethamphetamine (MDMA or 'ecstasy') and cannabis. The aim of the present study was to assess the acute effects of co-administration of MDMA and THC (the main psychoactive compound of cannabis) on pharmacokinetics, psychomotor performance, memory and subjective experience over time. We performed a four-way, double blind, randomized, crossover, placebo-controlled study in 16 healthy volunteers (12 male, four female) between the ages of 18 and 27. MDMA (100 mg) was given orally, THC (4, 6, and 6 mg, interval of 90 min) was vaporized and inhaled. THC induced more robust cognitive impairment compared with MDMA, and co-administration did not exacerbate single drug effects on cognitive function. However, co-administration of THC with MDMA increased desired subjective drug effects and drug strength compared with the MDMA condition, which may explain the widespread use of this combination.<p />  <p>Language: en</p>
LA  - en
SN  - 0269-8811
UR  - http://dx.doi.org/10.1177/0269881110376687
ID  - ref1
ER  -