TY  - JOUR
PY  - 1993//
TI  - Documentation of a doxylamine overdose death: quantitation by standard addition and use of three instrumental techniques
JO  - Journal of forensic sciences
A1  - Siek, T. J.
A1  - Dunn, W. A.
SP  - 713
EP  - 720
VL  - 38
IS  - 3
N2  - To answer the question, "Is this death due to a drug overdose?" requires at least that the drug be unequivocally identified and a blood concentration reliably determined. The approach taken in this case as standard addition technique and use of three different chromatographic techniques-high performance liquid chromatography (HPLC), high performance thin-layer chromatography (HP-TLC) and gas chromatography/mass spectrometry (GC/MS). Each of the chromatographies was carried out on the same extract by splitting the residue three ways. HPLC provided a quantitative result which was 1.2 mg/L in blood and HP-TLC and GC/MS confirmed this result with additional quantitative data, information about two metabolites (nordoxylamine and dinordoxylamine) and conclusive identification. Blood nordoxylamine was 0.52 mg/L and doxylamine plus metabolites in urine was 25 mg/L.<p /> <p>Language: en</p> 
LA  - en
SN  - 0022-1198
UR  - http://dx.doi.org/
ID  - ref1
ER  -