TY  - JOUR
PY  - 1996//
TI  - Serotonin 5-HT3 receptor binding kinetics in the cortex of suicide victims are normal
JO  - Journal of neural transmission
A1  - Mann, J. John
A1  - Arango, V.
A1  - Henteleff, R. A.
A1  - Lagattuta, T. F.
A1  - Wong, D. T.
SP  - 165
EP  - 171
VL  - 103
IS  - 1-2
N2  - Serotonergic abnormalities have been identified in the brain of suicide victims independent of psychiatric diagnosis. We report the first study of serotonin 5-HT3 receptors in the brain of suicide victims. There were no differences in the number (Bmax) or affinity (KD) of 5-HT3 receptors in the temporal cortex of suicide victims compared to matched controls. There was a negative correlation between brain serotonin levels and receptor number (r = -0.5, p = 0.04) in both groups. This study indicates that alterations in serotonergic function in the brain of suicide victims do not appear to directly involve the 5-HT3 receptor.<p /> <p>Language: en</p> 
LA  - en
SN  - 0300-9564
UR  - http://dx.doi.org/
ID  - ref1
ER  -