TY  - JOUR
PY  - 2008//
TI  - Biotechnological applications of brown spider (Loxosceles genus) venom toxins
JO  - Biotechnology advances
A1  - Senff-Ribeiro, Andrea
A1  - Henrique da Silva, Paulo
A1  - Chaim, Olga Meiri
A1  - Gremski, Luiza Helena
A1  - Paludo, Katia Sabrina
A1  - Bertoni da Silveira, Rafael
A1  - Gremski, Waldemiro
A1  - Mangili, Oldemir Carlos
A1  - Veiga, Silvio Sanches
SP  - 210
EP  - 218
VL  - 26
IS  - 3
N2  - Loxoscelism (the term used to define accidents by the bite of brown spiders) has been reported worldwide. Clinical manifestations following brown spider bites are frequently associated with skin degeneration, a massive inflammatory response at the injured region, intravascular hemolysis, platelet aggregation causing thrombocytopenia and renal disturbances. The mechanisms by which the venom exerts its noxious effects are currently under investigation. The whole venom is a complex mixture of toxins enriched with low molecular mass proteins in the range of 5-40 kDa. Toxins including alkaline phosphatase, hyaluronidase, metalloproteases (astacin-like proteases), low molecular mass (5.6-7.9 kDa) insecticidal peptides and phospholipases-D (dermonecrotic toxins) have been identified in the venom. The purpose of the present review is to describe biotechnological applications of whole venom or some toxins, with especial emphasis upon molecular biology findings obtained in the last years.<p /> <p>Language: en</p> 
LA  - en
SN  - 0734-9750
UR  - http://dx.doi.org/10.1016/j.biotechadv.2007.12.003
ID  - ref1
ER  -